Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry

Although mutations may represent attractive targets for immunotherapy, direct identification of mutated peptide ligands isolated from human leucocyte antigens (HLA) on the surface of native tumour tissue has so far not been successful. Using advanced mass spectrometry (MS) analysis, we survey the me...

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Foilsithe in:Nat Commun
Main Authors: Bassani-Sternberg, Michal, Bräunlein, Eva, Klar, Richard, Engleitner, Thomas, Sinitcyn, Pavel, Audehm, Stefan, Straub, Melanie, Weber, Julia, Slotta-Huspenina, Julia, Specht, Katja, Martignoni, Marc E., Werner, Angelika, Hein, Rüdiger, H. Busch, Dirk, Peschel, Christian, Rad, Roland, Cox, Jürgen, Mann, Matthias, Krackhardt, Angela M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121339/
https://ncbi.nlm.nih.gov/pubmed/27869121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13404
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