Soluble RANKL cleaved from activated lymphocytes by TNF-α converting enzyme (TACE) contributes to osteoclastogenesis in periodontitis

Host immune responses play a key role in promoting bone resorption in periodontitis via RANKL-dependent osteoclastogenesis. Both membrane-bound RANKL (mRANKL) expressed on lymphocytes and soluble RANKL (sRANKL) are found in periodontal lesions. However, the underlying mechanism and cellular source o...

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Published in:J Immunol
Main Authors: Kanzaki, Hiroyuki, Makihira, Seicho, Suzuki, Maiko, Ishii, Takenobu, Movila, Alexandru, Hirschfeld, Josefine, Mawardi, Hani, Lin, Xiaoping, Han, Xiaozhe, Taubman, Martin, Kawai, Toshihisa
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120874/
https://ncbi.nlm.nih.gov/pubmed/27815441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601114
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