EGFL6 regulates the asymmetric division, maintenance and metastasis of ALDH+ ovarian cancer cells

Little is known about the factors that regulate the asymmetric division of cancer stem-like cells. Here we demonstrate that EGFL6, a stem cell regulatory factor expressed in ovarian tumor cells and vasculature, regulates ALDH+ ovarian cancer stem-like cells (CSC). EGFL6 signaled at least in part via...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Bai, Shoumei, Ingram, Patrick, Chen, Yu-Chih, Deng, Ning, Pearson, Alex, Niknafs, Yashar, O'Hayer, Patrick, Wang, Yun, Zhang, Zhong-Yin, Boscolo, Elisa, Bischoff, Joyce, Yoon, Euisik, Buckanovich, Ronald J
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120866/
https://ncbi.nlm.nih.gov/pubmed/27803106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0225
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