Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23

BACKGROUND: Disulfide-rich peptides (DRPs) are found throughout nature. They are suitable scaffolds for drug development due to their small cores, whose disulfide bonds impart extraordinary chemical and biological stability. A challenge in developing a DRP therapeutic is to engineer binding to a spe...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Barkan, David T., Cheng, Xiao-li, Celino, Herodion, Tran, Tran T., Bhandari, Ashok, Craik, Charles S., Sali, Andrej, Smythe, Mark L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120537/
https://ncbi.nlm.nih.gov/pubmed/27881076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-016-1350-9
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