Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1

Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of the tissue type and urokinase type plasminogen activators. High levels of PAI-1 are correlated with an increased risk of thrombotic events and several other pathologies. Despite several compounds with in vitro activity being develope...

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Publicado no:Sci Rep
Main Authors: Pautus, Stéphane, Alami, Mouad, Adam, Fréderic, Bernadat, Guillaume, Lawrence, Daniel A., De Carvalho, Allan, Ferry, Gilles, Rupin, Alain, Hamze, Abdallah, Champy, Pierre, Bonneau, Natacha, Gloanec, Philippe, Peglion, Jean-Louis, Brion, Jean-Daniel, Bianchini, Elsa P., Borgel, Delphine
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120274/
https://ncbi.nlm.nih.gov/pubmed/27876785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36462
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