USP21 prevents the generation of T-helper-1-like Treg cells

FOXP3(+) Regulatory T (Treg) cells play a key role in the maintenance of immune homeostasis and tolerance. Disruption of Foxp3 expression results in the generation of instable Treg cells and acquisition of effector T-cell-like function. Here we report that the E3 deubiquitinase USP21 prevents the de...

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Publicado no:Nat Commun
Main Authors: Li, Yangyang, Lu, Yue, Wang, Shuaiwei, Han, Zhijun, Zhu, Fuxiang, Ni, Yingmeng, Liang, Rui, Zhang, Yan, Leng, Qibin, Wei, Gang, Shi, Guochao, Zhu, Ruihong, Li, Dan, Wang, Haikun, Zheng, Song Guo, Xu, Hongxi, Tsun, Andy, Li, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120220/
https://ncbi.nlm.nih.gov/pubmed/27857073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13559
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