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Positive and strongly relaxed purifying selection drive the evolution of repeats in proteins

Protein repeats are considered hotspots of protein evolution, associated with acquisition of new functions and novel phenotypic traits, including disease. Paradoxically, however, repeats are often strongly conserved through long spans of evolution. To resolve this conundrum, it is necessary to direc...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Persi, Erez, Wolf, Yuri I., Koonin, Eugene V
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120217/
https://ncbi.nlm.nih.gov/pubmed/27857066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13570
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