A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam

The effect of 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd) on proton-induced cell death was evaluated in human lung carcinoma cell line A549 and Chinese hamster fibroblast cell line V79 to enhance relative biological effectiveness (RBE) within the spread-out Bragg peak (SOBP) of proton bea...

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Bibliographic Details
Published in:PLoS One
Main Authors: Maeda, Kenichiro, Yasui, Hironobu, Yamamori, Tohru, Matsuura, Taeko, Takao, Seishin, Suzuki, Motofumi, Matsuda, Akira, Inanami, Osamu, Shirato, Hiroki
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119790/
https://ncbi.nlm.nih.gov/pubmed/27875573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166848
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