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Metabolic dysfunction in female mice with disruption of 5α-reductase 1
5α-Reductases irreversibly catalyse A-ring reduction of pregnene steroids, including glucocorticoids and androgens. Genetic disruption of 5α-reductase 1 in male mice impairs glucocorticoid clearance and predisposes to glucose intolerance and hepatic steatosis upon metabolic challenge. However, it is...
Enregistré dans:
| Publié dans: | J Endocrinol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Bioscientifica Ltd
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5118938/ https://ncbi.nlm.nih.gov/pubmed/27647861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-16-0125 |
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