Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene

Among the biologically active triterpenes, friedelin has the most-rearranged structure produced by the oxidosqualene cyclases and is the only one containing a cetonic group. In this study, we cloned and functionally characterized friedelin synthase and one cycloartenol synthase from Maytenus ilicifo...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Souza-Moreira, Tatiana M., Alves, Thaís B., Pinheiro, Karina A., Felippe, Lidiane G., De Lima, Gustavo M. A., Watanabe, Tatiana F., Barbosa, Cristina C., Santos, Vânia A. F. F. M., Lopes, Norberto P., Valentini, Sandro R., Guido, Rafael V. C., Furlan, Maysa, Zanelli, Cleslei F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118845/
https://ncbi.nlm.nih.gov/pubmed/27874020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36858
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