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A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts

The prompt identification of chemical molecules with potential effects on liver may help in drug discovery and in raising the levels of protection for human health. Besides in vitro approaches, computational methods in toxicology are drawing attention. We built a structure-activity relationship (SAR...

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Publicado en:Front Pharmacol
Main Authors: Pizzo, Fabiola, Lombardo, Anna, Manganaro, Alberto, Benfenati, Emilio
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118449/
https://ncbi.nlm.nih.gov/pubmed/27920722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00442
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