The role of Fas-associated phosphatase 1 in leukemia stem cell persistence during tyrosine kinase inhibitor treatment of chronic myeloid leukemia

Chronic myeloid leukemia (CML) is characterized by expression of Bcr-abl, a tyrosine kinase oncogene. Clinical outcomes in CML were revolutionized by development of Bcr-abl-targeted tyrosine kinase inhibitors (TKIs), but CML is not cured by these agents. CML leukemia stem cells (LSCs) are relatively...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Huang, W, Luan, C-H, Hjort, EE, Bei, L, Mishra, R, Sakamoto, KM, Platanias, LC, Eklund, EA
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117484/
https://ncbi.nlm.nih.gov/pubmed/26984787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.66
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