Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain

Cardiac muscle contraction requires sarcoplasmic reticulum (SR) Ca(2+) release mediated by the quaternary complex comprising the ryanodine receptor 2 (RyR2), calsequestrin 2 (CSQ2), junctin (encoded by ASPH) and triadin. Here, we demonstrate that a direct interaction exists between RyR2 and CSQ2. To...

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Bibliografiske detaljer
Udgivet i:J Cell Sci
Main Authors: Handhle, Ahmed, Ormonde, Chloe E., Thomas, N. Lowri, Bralesford, Catherine, Williams, Alan J., Lai, F. Anthony, Zissimopoulos, Spyros
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2016
Fag:
Short Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117208/
https://ncbi.nlm.nih.gov/pubmed/27609834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.191643
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