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Tril targets Smad7 for degradation to allow hematopoietic specification in Xenopus embryos

In Xenopus laevis, bone morphogenetic proteins (Bmps) induce expression of the transcription factor Gata2 during gastrulation, and Gata2 is required in both ectodermal and mesodermal cells to enable mesoderm to commit to a hematopoietic fate. Here, we identify tril as a Gata2 target gene that is req...

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Bibliografiske detaljer
Udgivet i:Development
Main Authors: Green, Yangsook Song, Kwon, Sunjong, Mimoto, Mizuho S., Xie, Yuanyuan, Christian, Jan L.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117148/
https://ncbi.nlm.nih.gov/pubmed/27633996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.141812
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