Toll-Like Receptor 2 Recognizes Orientia tsutsugamushi and Increases Susceptibility to Murine Experimental Scrub Typhus

Scrub typhus is a potentially lethal infection that is caused by the obligate intracellular bacterium Orientia tsutsugamushi. The roles of Toll-like receptor 2 (TLR2) and TLR4 in innate recognition of O. tsutsugamushi have not been elucidated. By overexpression of TLR2 or TLR4 in HEK293 cells, we de...

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Gharaibeh, Mohammad, Hagedorn, Monica, Lilla, Stefanie, Hauptmann, Matthias, Heine, Holger, Fleischer, Bernhard, Keller, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Bacterial Infections
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116716/
https://ncbi.nlm.nih.gov/pubmed/27620720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00185-16
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