Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

Emerging evidence from the current outbreak of Zika virus (ZIKV) indicates a strong causal link between Zika and microcephaly. To investigate how ZIKV infection leads to microcephaly, we used human embryonic stem cell-derived cerebral organoids to recapitulate early stage, first trimester fetal brai...

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Publicado en:Cell Stem Cell
Autores principales: Dang, Jason, Tiwari, Shashi Kant, Lichinchi, Gianluigi, Qin, Yue, Patil, Veena S., Eroshkin, Alexey M., Rana, Tariq M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116380/
https://ncbi.nlm.nih.gov/pubmed/27162029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.04.014
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