Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage

BACKGROUND: We investigated two distinct synovial fibroblast populations that were located preferentially in the lining or sub-lining layers and defined by their expression of either podoplanin (PDPN) or CD248, and explored their ability to undergo self-assembly and transmigration in vivo. METHODS:...

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Veröffentlicht in:Arthritis Res Ther
Hauptverfasser: Croft, Adam P., Naylor, Amy J., Marshall, Jennifer L., Hardie, Debbie L., Zimmermann, Birgit, Turner, Jason, Desanti, Guillaume, Adams, Holly, Yemm, Adrian I., Müller-Ladner, Ulf, Dayer, Jean-Michel, Neumann, Elena, Filer, Andrew, Buckley, Christopher D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116193/
https://ncbi.nlm.nih.gov/pubmed/27863512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-1156-1
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