Defective autophagy leads to the suppression of stem-like features of CD271(+) osteosarcoma cells

BACKGROUND: As an important stress-response mechanism, autophagy plays crucial role in the tumor formation and drug resistance of cancer cells including osteosarcoma (OS). OS cancer stem cells (CSCs) also are considered a key factor of tumorigenesis, drug resistance and tumor recurrence. However, th...

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Publicado en:J Biomed Sci
Autores principales: Zhang, Dong, Zhao, Qing, Sun, Hao, Yin, Lijuan, Wu, Jiajun, Xu, Jun, He, Tianxiang, Yang, Chunlei, Liang, Chengwei
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116184/
https://ncbi.nlm.nih.gov/pubmed/27863492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-016-0297-5
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