Estimation of tulathromycin depletion in plasma and milk after subcutaneous injection in lactating goats using a nonlinear mixed-effects pharmacokinetic modeling approach

BACKGROUND: Extra-label use of tulathromycin in lactating goats is common and may cause violative residues in milk. The objective of this study was to develop a nonlinear mixed-effects pharmacokinetic (NLME-PK) model to estimate tulathromycin depletion in plasma and milk of lactating goats. Eight la...

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Bibliographic Details
Published in:BMC Vet Res
Main Authors: Lin, Zhoumeng, Cuneo, Matthew, Rowe, Joan D., Li, Mengjie, Tell, Lisa A., Allison, Shayna, Carlson, Jan, Riviere, Jim E., Gehring, Ronette
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116175/
https://ncbi.nlm.nih.gov/pubmed/27863483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12917-016-0884-4
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