Risks of first and subsequent cancers among TP53 mutation-carriers in the NCI LFS cohort

BACKGROUND: Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer predisposition syndrome characterized by very high lifetime cancer risk and early age at diagnosis of a wide cancer spectrum. Precise estimates for first and subsequent cancers risk are lacking. METHODS: The NCI’s LFS Study inclu...

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Veröffentlicht in:Cancer
Hauptverfasser: Mai, Phuong L., Best, Ana F., Peters, June A., DeCastro, Rosamma, Khincha, Payal P., Loud, Jennifer T., Bremer, Renée C., Rosenberg, Philip S., Savage, Sharon A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115949/
https://ncbi.nlm.nih.gov/pubmed/27496084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30248
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