The Ability of a Non-Egg Adapted (Cell-Like) A(H1N1)pdm09 Virus to Egg-Adapt at HA Loci Other than 222 and 223 and Its Effect on the Yield of Viral Protein

Previous studies on influenza A(H1N1)pdm09 candidate vaccine viruses (CVVs) that had adapted to growth in embryonated chicken eggs by the acquisition of amino acid substitutions at HA positions 222 or 223 showed that improved protein yield could be conferred by additional amino acid substitutions in...

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Udgivet i:PLoS One
Main Authors: Nicolson, Carolyn, Harvey, Ruth, Engelhardt, Othmar G., Robertson, James S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115798/
https://ncbi.nlm.nih.gov/pubmed/27861557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166761
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