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D-3-deoxy-dioctanoylphosphatidylinositol Induces Cytotoxicity in Human MCF-7 Breast Cancer Cells via a Mechanism that Involves Downregulation of the D-type Cyclin-Retinoblastoma Pathway
Phosphatidylinositol analogs (PIAs) were originally designed to bind competitively to the Akt PH domain and prevent membrane translocation and activation. D-3-deoxydioctanoylphosphatidylinositol (D-3-deoxy-diC(8)PI), but not compounds with altered inositol stereochemistry (e.g., L-3-deoxy-diC(8)PI a...
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| 出版年: | Biochim Biophys Acta |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5115159/ https://ncbi.nlm.nih.gov/pubmed/27600289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2016.09.001 |
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