D-3-deoxy-dioctanoylphosphatidylinositol Induces Cytotoxicity in Human MCF-7 Breast Cancer Cells via a Mechanism that Involves Downregulation of the D-type Cyclin-Retinoblastoma Pathway

Phosphatidylinositol analogs (PIAs) were originally designed to bind competitively to the Akt PH domain and prevent membrane translocation and activation. D-3-deoxydioctanoylphosphatidylinositol (D-3-deoxy-diC(8)PI), but not compounds with altered inositol stereochemistry (e.g., L-3-deoxy-diC(8)PI a...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Gradziel, Cheryl S., Jordan, Peter A., Jewel, Delilah, Dufort, Fay J., Miller, Scott J., Chiles, Thomas C., Roberts, Mary F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115159/
https://ncbi.nlm.nih.gov/pubmed/27600289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2016.09.001
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