Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding–Defective Mutant of ABIN1

Polymorphisms in the TNIP1 gene encoding A20-binding inhibitor of NF-κB1 (ABIN1) predispose to lupus and other autoimmune diseases in at least eight human populations. We found previously that knock-in mice expressing a ubiquitin-binding–defective mutant of ABIN1 (ABIN1[D485N]) develop autoimmunity...

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Udgivet i:J Immunol
Main Authors: Nanda, Sambit K., Lopez-Pelaez, Marta, Arthur, J. Simon C., Marchesi, Francesco, Cohen, Philip
Format: Artigo
Sprog:Inglês
Udgivet: AAI 2016
Fag:
Autoimmunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114882/
https://ncbi.nlm.nih.gov/pubmed/27807192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600788
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