The pharmacophore of debromoaplysiatoxin responsible for protein kinase C activation.
Protein kinase C is physiologically activated by 1,2-diacyl-sn-glycerol in the S configuration. The enzyme is also powerfully activated by structurally diverse tumor promotors. A model has been developed that demonstrates how the various tumor promotors and diacylglycerols can all be accommodated by...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1991
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51148/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2000401/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.5.1973 |
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