“Threshold‐crossing”: A Useful Way to Establish the Counterfactual in Clinical Trials?

A central question in the assessment of benefit/harm of new treatments is: how does the average outcome on the new treatment (the factual) compare to the average outcome had patients received no treatment or a different treatment known to be effective (the counterfactual)? Randomized controlled tria...

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Bibliographische Detailangaben
Veröffentlicht in:Clin Pharmacol Ther
Hauptverfasser: Eichler, H‐G, Bloechl‐Daum, B, Bauer, P, Bretz, F, Brown, J, Hampson, LV, Honig, P, Krams, M, Leufkens, H, Lim, R, Lumpkin, MM, Murphy, MJ, Pignatti, F, Posch, M, Schneeweiss, S, Trusheim, M, Koenig, F
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
State of the Art
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114686/
https://ncbi.nlm.nih.gov/pubmed/27650716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.515
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