Intermedin(1–53) Protects Against Myocardial Fibrosis by Inhibiting Endoplasmic Reticulum Stress and Inflammation Induced by Homocysteine in Apolipoprotein E-Deficient Mice

Aim: Endoplasmic reticulum stress (ERS) and inflammation participate in cardiac fibrosis. Importantly, a novel paracrine/autocrine peptide intermedin(1–53) (IMD(1–53)) in the heart inhibits myocardial fibrosis in rats. However, the mechanisms are yet to be fully elucidated. Methods: Myocardial fibro...

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Publicado en:J Atheroscler Thromb
Autores principales: Zhang, Jin-Sheng, Hou, Yue-Long, Lu, Wei-Wei, Ni, Xian-Qiang, Lin, Fan, Yu, Yan-Rong, Tang, Chao-Shu, Qi, Yong-Fen
Formato: Artigo
Lenguaje:Inglês
Publicado: Japan Atherosclerosis Society 2016
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113747/
https://ncbi.nlm.nih.gov/pubmed/27052784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5551/jat.34082
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