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Postarrest stalling rather than crawling favors CD8(+) over CD4(+) T‐cell migration across the blood–brain barrier under flow in vitro

Although CD8(+) T cells have been implied in the pathogenesis of multiple sclerosis (MS), the molecular mechanisms mediating CD8(+) T‐cell migration across the blood–brain barrier (BBB) into the central nervous system (CNS) are ill defined. Using in vitro live cell imaging, we directly compared the...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Rudolph, Henriette, Klopstein, Armelle, Gruber, Isabelle, Blatti, Claudia, Lyck, Ruth, Engelhardt, Britta
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113696/
https://ncbi.nlm.nih.gov/pubmed/27338806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201546251
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