Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway

Abnormal survival of retinal pigment epithelium (RPE) cells contributes to the pathogenesis of proliferative vitreoretinopathy (PVR), a sight-threatening disease. In this study, we explored the effect of the anti-rheumatic agent auranofin (AF) on RPE cell survival and studied the underlying signalin...

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Udgivet i:PLoS One
Main Authors: Chen, Xiaodong, Tzekov, Radouil, Su, Mingyang, Hong, Haiyan, Min, Wang, Han, Aidong, Li, Wensheng
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5112952/
https://ncbi.nlm.nih.gov/pubmed/27846303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166386
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