Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain

Piwi-interacting RNAs (piRNAs), long thought to be restricted to germline, have recently been discovered in neurons of Aplysia, with a role in the epigenetic regulation of gene expression underlying long-term memory. We here ask whether piwi/piRNAs are also expressed and have functional roles in the...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Nandi, Sayan, Chandramohan, Dhruva, Fioriti, Luana, Melnick, Ari M., Hébert, Jean M., Mason, Christopher E., Rajasethupathy, Priyamvada, Kandel, Eric R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111663/
https://ncbi.nlm.nih.gov/pubmed/27791114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609287113
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