Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research

We previously reported that tumor vessel-redirected T cells, which were genetically engineered with chimeric antigen receptor (CAR) specific for vascular endothelial growth factor receptor 2 (VEGFR2), demonstrated significant antitumor effects in various murine solid tumor models. In the present stu...

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Udgivet i:Mol Ther Oncolytics
Main Authors: Inoo, Kanako, Inagaki, Ryo, Fujiwara, Kento, Sasawatari, Shigemi, Kamigaki, Takashi, Nakagawa, Shinsaku, Okada, Naoki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111575/
https://ncbi.nlm.nih.gov/pubmed/27909701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2016.24
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