Changes in ceftriaxone pharmacokinetics/pharmacodynamics during the early phase of sepsis: a prospective, experimental study in the rat

BACKGROUND: Sepsis is characterized by the loss of the perm-selectivity properties of the glomerular filtration barrier (GFB) with consequent albuminuria. We examined whether the pharmacokinetics–pharmacodynamics (PK/PD) of ceftriaxone (CTX), an extensively protein-bound 3rd generation cephalosporin...

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Bibliographic Details
Published in:J Transl Med
Main Authors: Selmi, Valentina, Loriga, Beatrice, Vitali, Luca, Carlucci, Martina, Di Filippo, Alessandro, Carta, Giulio, Sgambati, Eleonora, Tofani, Lorenzo, De Gaudio, Angelo Raffaele, Novelli, Andrea, Adembri, Chiara
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111190/
https://ncbi.nlm.nih.gov/pubmed/27846855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-1072-9
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