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Distinct stoichiometry of BK(Ca) channel tetramer phosphorylation specifies channel activation and inhibition by cAMP-dependent protein kinase

Large conductance voltage- and calcium-activated potassium (BK(Ca)) channels are important signaling molecules that are regulated by multiple protein kinases and protein phosphatases at multiple sites. The pore-forming α-subunits, derived from a single gene that undergoes extensive alternative pre-m...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Tian, Lijun, Coghill, Lorraine S., McClafferty, Heather, MacDonald, Stephen H.-F., Antoni, Ferenc A., Ruth, Peter, Knaus, Hans-Guenther, Shipston, Michael J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC511071/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15280542/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402590101
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