Targeting cell division: Small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality

FtsZ, the ancestral homolog of eukaryotic tubulins, is a GTPase that assembles into a cytokinetic ring structure essential for cell division in prokaryotic cells. Similar to tubulin, purified FtsZ polymerizes into dynamic protofilaments in the presence of GTP; polymer assembly is accompanied by GTP...

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Detalhes bibliográficos
Main Authors: Margalit, Danielle N., Romberg, Laura, Mets, Rebecca B., Hebert, Alan M., Mitchison, Timothy J., Kirschner, Marc W., RayChaudhuri, Debabrata
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC511058/
https://ncbi.nlm.nih.gov/pubmed/15289600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404439101
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