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Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

Signal transducer and activator of transcription 3 (STAT3) protects the heart from acute ischemic stress. However, the importance of STAT3 to the heart in chronic stress, such as hypertension, is not known. To study this, we used cardiomyocyte-targeted STAT3 knockout (KO) mice and Angiotensin II (AN...

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Bibliografische gegevens
Gepubliceerd in:Front Pharmacol
Hoofdauteurs: Altara, Raffaele, Harmancey, Romain, Didion, Sean P., Booz, George W., Zouein, Fouad A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110511/
https://ncbi.nlm.nih.gov/pubmed/27899891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00436
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