A Novel Benzodiazepine Compound Inhibits Yellow Fever Virus Infection by Specifically Targeting NS4B Protein

Although a highly effective vaccine is available, the number of yellow fever cases has increased over the past 2 decades, which highlights the pressing need for antiviral therapeutics. In a high-throughput screening campaign, we identified an acetic acid benzodiazepine (BDAA) compound which potently...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Guo, Fang, Wu, Shuo, Julander, Justin, Ma, Julia, Zhang, Xuexiang, Kulp, John, Cuconati, Andrea, Block, Timothy M., Du, Yanming, Guo, Ju-Tao, Chang, Jinhong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110185/
https://ncbi.nlm.nih.gov/pubmed/27654301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01253-16
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