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FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes

IgG (mAb)-opsonized, inactivated Francisella tularensis LVS (iFt-mAb) enhances TLR2-dependent IL-6 production by macrophages via Fcγ receptors (FcγR). In mice, vaccination with iFt-mAb provides IgA-dependent protection against lethal challenge with Ft LVS. Because inflammasome maturation of IL-1β is...

詳細記述

保存先:
書誌詳細
出版年:J Leukoc Biol
主要な著者: Duffy, Ellen B., Periasamy, Sivakumar, Hunt, Danielle, Drake, James R., Harton, Jonathan A.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Leukocyte Biology 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110000/
https://ncbi.nlm.nih.gov/pubmed/27365531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.2A1215-555RR
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