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Dynamic Local Polymorphisms in the Gbx1 Homeodomain Induced by DNA Binding
The Gastrulation Brain Homeobox 1 (Gbx1) gene encodes the Gbx1 homeodomain that targets TAATTA motifs in dsDNA. Residues Glu17 and Arg52 in Gbx1 form a salt bridge, which is preserved in crystal structures and MD simulations of homologous homeodomain–DNA complexes. In contrast, our NMR studies show...
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| Publié dans: | Structure |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5109927/ https://ncbi.nlm.nih.gov/pubmed/27396829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.05.013 |
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