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Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress

Thioredoxin reductase 1 (TrxR1) is a pivotal intracellular redox sensor and antioxidant enzyme. On the other hand, overexpression of TrxR1 is closely correlated with the initiation of various tumors including breast cancer, though the detailed mechanism remains unclear. Here we investigated the role...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dong, Chaoran, Zhang, Lei, Sun, Ruoxuan, Liu, Jianying, Yin, Hanwei, Li, Xiaoxiao, Zheng, Xiaoqing, Zeng, Huihui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109291/
https://ncbi.nlm.nih.gov/pubmed/27845427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36860
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