Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ(12,14)-Prostaglandin J(2) (15d-PGJ(2)) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4(+)CD25(−)FOXP3(+) Cells

The prostaglandin, 15-deoxy Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)), is a lipid mediator that plays an important role in the control of chronic inflammatory disease. However, the role of prostanoid in rheumatoid arthritis (RA) is not well determined. We demonstrated the therapeutic effect of 15d-PG...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Carregaro, Vanessa, Napimoga, Marcelo H., Peres, Raphael S., Benevides, Luciana, Sacramento, Laís Amorim, Pinto, Larissa G., Grespan, Renata, Cunha, Thiago M., da Silva, João Santana, Cunha, Fernando Q.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107840/
https://ncbi.nlm.nih.gov/pubmed/27872515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9626427
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