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HIV-1 Tat causes cognitive deficits and selective loss of parvalbumin, somatostatin, and neuronal nitric oxide synthase expressing hippocampal CA1 interneuron subpopulations

Memory deficits are characteristic of HIV-associated neurocognitive disorders (HAND) and co-occur with hippocampal pathology. The HIV-1 transactivator of transcription (Tat), a regulatory protein, plays a significant role in these events, but the cellular mechanisms involved are poorly understood. W...

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Vydáno v:J Neurovirol
Hlavní autoři: Marks, William D., Paris, Jason J., Schier, Christina J., Denton, Melissa D., Fitting, Sylvia, McQuiston, A. Rory, Knapp, Pamela E., Hauser, Kurt F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107352/
https://ncbi.nlm.nih.gov/pubmed/27178324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13365-016-0447-2
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