Breast cancer risk prediction using a polygenic risk score in the familial setting: a prospective study from the Breast Cancer Family Registry and kConFab

PURPOSE: This study examined the utility of sets of Single Nucleotide Polymorphisms (SNPs) in familial but non-BRCA-associated breast cancer (BC). METHODS: We derived a polygenic risk score (PRS) based on 24 known BC risk SNPs for 4,365 women from the BCFR and kConFab familial BC cohorts. We compare...

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Udgivet i:Genet Med
Main Authors: Li, Hongyan, Feng, Bingjian, Miron, Alexander, Chen, Xiaoqing, Beesley, Jonathan, Bimeh, Emmanuella, Barrowdale, Daniel, John, Esther M., Daly, Mary B., Andrulis, Irene L., Buys, Saundra S., Kraft, Peter, Thorne, Heather, Chenevix-Trench, Georgia, Southey, Melissa, Antoniou, Antonis C., James, Paul A., Terry, Mary Beth, Phillips, Kelly-Anne, Hopper, John L., Mitchell, Gillian, Goldgar, David E.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107177/
https://ncbi.nlm.nih.gov/pubmed/27171545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gim.2016.43
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