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Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions
Hypoxia-inducible transcription factors (HIFs) control adaptation to low oxygen environments by activating genes involved in metabolism, angiogenesis, and redox homeostasis. The finding that HIFs are also regulated by small molecule metabolites highlights the need to understand the complexity of the...
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Vydáno v: | Cell Metab |
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Hlavní autoři: | , , , , , , , , , , |
Médium: | Artigo |
Jazyk: | Inglês |
Vydáno: |
Cell Press
2016
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Témata: | |
On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5106373/ https://ncbi.nlm.nih.gov/pubmed/27923773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.09.015 |
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