p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress

DNA replication initiation is a key event in the cell cycle, which is dependent on 2 kinases - CDK2 and CDC7. Here we report a novel mechanism in which p53 induces G1 checkpoint and cell cycle arrest by downregulating CDC7 kinase in response to genotoxic stress. We demonstrate that p53 controls CDC7...

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Publicado en:Cell Cycle
Main Authors: Tudzarova, Slavica, Mulholland, Paul, Dey, Ayona, Stoeber, Kai, Okorokov, Andrei L., Williams, Gareth H.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2016
Assuntos:
Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105930/
https://ncbi.nlm.nih.gov/pubmed/27611229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1231281
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