BACE1 RNAi Restores the Composition of Phosphatidylethanolamine-Derivates Related to Memory Improvement in Aged 3xTg-AD Mice

β-amyloid (Aβ) is produced by the β-secretase 1 (BACE1)-mediated enzymatic cleavage of the amyloid precursor protein through the amyloidogenic pathway, making BACE1 a therapeutic target against Alzheimer’s disease (AD). Alterations in lipid metabolism are a risk factor for AD by an unknown mechanism...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Villamil-Ortiz, Javier G., Barrera-Ocampo, Alvaro, Piedrahita, Diego, Velásquez-Rodríguez, Claudia M., Arias-Londoño, Julian D., Cardona-Gómez, Gloria P.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105502/
https://ncbi.nlm.nih.gov/pubmed/27891075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2016.00260
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