BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization

BMI1 is a core component of the polycomb repressive complex 1 (PRC1) and emerging data support a role of BMI1 in cancer. The central domain of BMI1 is involved in protein–protein interactions and is essential for its oncogenic activity. Here, we present the structure of BMI1 bound to the polyhomeoti...

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Publicado en:Nat Commun
Main Authors: Gray, Felicia, Cho, Hyo Je, Shukla, Shirish, He, Shihan, Harris, Ashley, Boytsov, Bohdan, Jaremko, Łukasz, Jaremko, Mariusz, Demeler, Borries, Lawlor, Elizabeth R., Grembecka, Jolanta, Cierpicki, Tomasz
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105191/
https://ncbi.nlm.nih.gov/pubmed/27827373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13343
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