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Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity

Many biopharmaceutical products exhibit extensive structural micro-heterogeneity due to an array of co-occurring post-translational modifications. These modifications often effect the functionality of the product and therefore need to be characterized in detail. Here, we present an integrative appro...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yang, Yang, Liu, Fan, Franc, Vojtech, Halim, Liem Andhyk, Schellekens, Huub, Heck, Albert J. R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105167/
https://ncbi.nlm.nih.gov/pubmed/27824045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13397
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