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Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound.

9-(2-Phosphonylmethoxyethyl)adenine (PMEA) is a potent and selective inhibitor of retrovirus (i.e., human immunodeficiency virus) replication in vitro and in vivo. Uptake of PMEA by human MT-4 cells and subsequent conversion to the mono- and diphosphorylated metabolites (PMEAp and PMEApp) are dose-d...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Balzarini, J, Hao, Z, Herdewijn, P, Johns, D G, De Clercq, E
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51046/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1705039/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.4.1499
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