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Cytosolic accumulation of L-proline disrupts GABA-ergic transmission through GAD blockade
Proline dehydrogenase (PRODH), which degrades L-proline, resides within the schizophrenia-linked 22q11.2 deletion suggesting a role in disease. Supporting this, elevated L-proline levels have been shown to increase risk for psychotic disorders. Despite the strength of data linking PRODH and L-prolin...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5104186/ https://ncbi.nlm.nih.gov/pubmed/27705802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.09.029 |
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