Organic cation transporter 6 directly confers resistance to anticancer platinum drugs

Organic cation transporters (OCTs) of the solute carrier family 22 have a critical role in the cellular uptake of anticancer platinum drugs. Recently, we found that a decreased OCT6 expression is associated with a reduced intracellular uptake of cisplatin (CDDP), and concomitant resistance to CDDP....

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Veröffentlicht in:Biomed Rep
Hauptverfasser: Oguri, Tetsuya, Kunii, Eiji, Fukuda, Satoshi, Sone, Kazuki, Uemura, Takehiro, Takakuwa, Osamu, Kanemitsu, Yoshihiro, Ohkubo, Hirotsugu, Takemura, Masaya, Maeno, Ken, Ito, Yutaka, Niimi, Akio
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5103690/
https://ncbi.nlm.nih.gov/pubmed/27882231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/br.2016.772
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